SARS-CoV-2
Is Bradykinin Involved in Covid-19 Pathogenesis?
Is Bradykinin Involved in Covid-19 Pathogenesis? March 18, 2022 Inflammation One of the hallmarks of Covid-19 disease is inflammation, mediated in part by overproduction of inflammatory cytokines. However, the mechanisms of such inflammatory process have not been clearly understood. In the past year the potential role of bradykinin, a small peptide and a members of…
Read MoreCOVID-19 and the Gut Microbiome
February 11, 2022 Effects of Microbiomes The importance of the immunomodulatory effects of gut microbial populations has now been well recognized. In addition to their normal beneficial effects, alterations in the gut microbiota composition can lead to profound immune dysregulation and systemic inflammation. Because severe COVID-19 and long term COVID are driven by inappropriate immune…
Read MoreCell-Mediated and Innate Immunity Against SARS-CoV-2: What is Known
Cell-Mediated and Innate Immunity Against SARS-CoV-2: What is Known January 26, 2022 Titers of neutralizing antibodies (nAbs) against SARS-CoV-2 have proven a reasonable predictor of protection against infection and disease. However, T cell responses (CD8+ and CD4+), innate immune mechanisms, and Fc-mediated cellular cytotoxicity can also provide protective immunity against the virus. T cells The…
Read MoreOmicron: Transmissibility, Immune Evasion, and Pathogenicity
Omicron: Transmissibility, Immune Evasion, and Pathogenicity January 13, 2022 We are currently in a wave of SARS-CoV-2 infections dominated by the recently discovered omicron variant. What new threats does it pose? It is clearly able to overcome immune barriers to infection. Also, this variant is far more transmissible than others, making it an hyper transmissible…
Read MoreDeltacron: a new variant or a laboratory contamination?
Deltacron: a new variant or a laboratory contamination? Scientists have recently reported the emergence of new SARS-CoV-2 variant, “Deltacron”, resulting from the recombination of Omicron and Delta variants in infected patients. According to a GVN scientist, Deltacron is not a new variant, but the result of laboratory contamination. His sequence analysis suggests that the Omicron…
Read MoreGVN and Monaco COVID-19 Diagnostic Conference: Executive Summary
A December 2-3, 2021 Conference Towards the Deployment of a Global and Collaborative Diagnostic Arsenal to Detect and Fight Against Pandemics Amid global spread of the Omicron variant, under the High Patronage of H.S.H. Prince Albert II of Monaco, the Global Virus Network(GVN), the Centre Scientifique de Monaco, the Fondation Prince Albert II de Monaco,…
Read MoreGVN and Monaco COVID-19 Diagnostic Conference: Promises and Challenges
GVN and Monaco COVID-19 Diagnostic Conference: Promises and Challenges Thursday, December 02, 2021 – Friday, December 03, 2021 Towards the deployment of a global and collaborative diagnostic arsenal to detect and fight against pandemics November 30, 2021: The current COVID-19 pandemic, and in particular the proliferation of variants such as Omicron, again emphasize the importance of…
Read MoreGlobal Spread of Omicron, New Variant of Concern
Global Spread of Omicron, New Variant of Concern November 29, 2021 The first known confirmed Omicron (B.1.1.529) infection was from a specimen collected on November 9, 2021. The variant quickly became a new variant of concern because of its rapid spread in South Africa and globally, as well as the large number of mutations found…
Read MoreGVN and Monaco COVID-19 Diagnostic Conference: Promises and Challenges
GVN and Monaco COVID-19 Diagnostic Conference: Promises and Challenges Thursday, December 02, 2021 – Friday, December 03, 2021 Towards the deployment of a global and collaborative diagnostic arsenal to detect and fight against pandemics The current COVID-19 pandemic has again emphasized the importance of accurate, rapid, and massively deployed diagnostics to effectively contain viral transmission.…
Read MoreNew Antivirals: Could They Be Game Changers?
New Antivirals: Could They Be Game Changers? November 1, 2021 There have been recent reports of potentially effective oral antiviral drugs, including RNA replicase and viral protease inhibitors. If these prove safe and effective, this may overhaul the care of patients with COVID-19 by preventing severe COVID-19 in infected patients and, possibly in the future,…
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