Posts by GVN
Impact of Interferon on Disease Severity of COVID-19
March 28, 2022 INTRODUCTION Types 1 and 3 interferon (IFN) expression and activity have been shown to play a significant role in determining the disease severity of SARS-CoV-2 infection. It is becoming clear that the timing of IFN expression is critical in the efficacy of the early response to viral infection on reducing disease severity.…
Read MoreIs Bradykinin Involved in COVID-19 Pathogenesis?
March 18, 2022 INFLAMMATION One of the hallmarks of Covid-19 disease is inflammation, mediated in part by overproduction of inflammatory cytokines. However, the mechanisms of such inflammatory process have not been clearly understood. In the past year the potential role of bradykinin, a small peptide and a members of family kinins, in the pathogenesis of…
Read MoreCOVID-19 and the Gut Microbiome
February 11, 2022 EFFECTS OF MICROBIOMES The importance of the immunomodulatory effects of gut microbial populations has now been well recognized. In addition to their normal beneficial effects, alterations in the gut microbiota composition can lead to profound immune dysregulation and systemic inflammation. Because severe COVID-19 and long term COVID are driven by inappropriate immune…
Read MoreCell-Mediated and Innate Immunity Against SARS-COV-2: What is Known
January 26, 2022 Titers of neutralizing antibodies (nAbs) against SARS-CoV-2 have proven a reasonable predictor of protection against infection and disease. However, T cell responses (CD8+ and CD4+), innate immune mechanisms, and Fc-mediated cellular cytotoxicity can also provide protective immunity against the virus. T CELLS The role of T cell activities in correlates of protection…
Read MoreOmicron: Transmissibility, Immune Evasion, and Pathogenicity
January 13, 2022 We are currently in a wave of SARS-CoV-2 infections dominated by the recently discovered omicron variant. What new threats does it pose? It is clearly able to overcome immune barriers to infection. Also, this variant is far more transmissible than others, making it an hyper transmissible variant. However, there may be a…
Read MoreLangya Virus
Langya Virus August 15, 2022 A sentinel surveillance study in China has detected the zoonotic Langya henipavirus (Paramyxoviridae) in 35 patients. RNA of the virus was found in 27% of shrews in the wild, revealing a potential animal reservoir. Zoonotic transmission is the first step potentially leading to “jumps” across species. Currently, there is no evidence of…
Read MoreGlobal Virus Network (GVN) Convenes First-Of-Its-Kind Conference To Evaluate The Public Health Magnitude Of Long-COVID And Define A Global Research Roadmap To Address The Crisis
World Leaders in Science, Healthcare, Academia, Business and Government Discuss Issues and Ramifications of Long Covid Baltimore, MD, USA (July 22, 2022) – The Global Virus Network (GVN), a coalition of world leading medical virology research centers, yesterday concluded a two-day gathering on the ‘Science of Long COVID.’ The first-of-its-kind conference reviewed the wealth of cohort…
Read MoreU.S. Senate Committee on Appropriations Full Committee Hearing “U.S. Government Response: Fighting Ebola and Protecting America” Wednesday, November 12, 2014 Testimony submitted by: Global Virus Network (GVN)
Robert C. Gallo, MD, GVN Co-Founder and Scientific Director, and Director of GVN Center of Excellence at the Institute of Human Virology (IHV), University of Maryland School of Medicine; Stanley Plotkin, MD, GVN Senior Advisor, University of Pennsylvania; Diane Griffin, MD PhD, GVN Center of Excellence Director at the Johns Hopkins Bloomberg School of Public…
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