Long COVID: The Impact of Post-Acute Sequelae of COVID-19 (PASC)
November 12, 2021
There is mounting evidence of the importance and seriousness of the long-term effects of COVID-19. Post-acute sequelae of SARS-CoV-2 (PASC, or “long COVID”) is characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms (1). Approximately 80% of individuals with a confirmed COVID-19 diagnosis continue to have COVID-19 symptoms or the emergence of new ones following acute infection (2, 3). Since COVID-19 can affect the function of multiple organs in the body, including the lungs, heart, brain, kidneys, and liver, people are experiencing a broad range of sequelae, such as neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain, and anemia. Commonly reported symptoms include fatigue, shortness of breath, “brain fog”, sleep disorders, fevers, gastrointestinal symptoms, anxiety, and depression (4). It can be observed after asymptomatic, as well as mild or severe, COVID-19.