Role of Correlates of Protection, or Immune Measurements, in Predicting Protective Immunity of COVID-19 Vaccines
March 29, 2021
Broadly speaking, correlates of protection are measurements of immune parameters that allow prediction of the degree of protection against infection or disease induced by a pathogen. A prime point of interest in consideration of protection against SARS-CoV-2 and COVID-19 is: what are the relevant correlates of protection? These, unfortunately, are not yet completely understood. Firstly, protection could mean protection from detectable infection (also known as sterilizing immunity), protection from symptomatic infection, or protection from severe disease. Secondly, it is likely that there is not only one protective mechanism, but that components of innate, B-cell and T-cell immunities can synergistically play important roles in protection. Correlates of protection and their induction and durability will need to be understood to effectively open society in the post-vaccination stage of the pandemic.