Dr Yi-Hao Chan completed his PhD with the A*STAR Graduate Scholarship on immune pathogenesis of alphaviruses. He was then awarded the A*STAR International Fellowship to pursue his postdoctoral training in Rockefeller University in New York, USA, under the tutelage of Dr Jean-Laurent Casanova, working on neuron-intrinsic antiviral factors that predispose patients to Herpes Simplex Encephalitis and isolated SARS-CoV-2 Encephalitis. During his training, he reported human TMEFF1 as the first discovered HSV-1 restriction factor in the brain in Nature. He also reported DBR1 deficiency as a genetic etiology of isolated SARS-CoV-2 encephalitis in Journal of Experimental Medicine. He co-authored multiple studies on inborn errors of immunity underlying MIS-C, MSMD and HSE, published in Science, Cell, and Science Immunology. He was awarded the RUCCTS pilot grant from the Shapiro-Silverberg Fund for the Advancement of Translational Research. Currently, Yi-Hao is leading a team at A*STAR Infectious Diseases Labs to study genetic and immunological determinants of life-threatening viral diseases. He is an associate editor for the Viral Immunology section at Frontiers in Immunology and an editor for the Journal of Human Immunity. He is also the recipient of A*STAR Young Achiever award in 2023 and the National Research Foundation Fellowship in 2025.