News and Publications

Important News and Publications

Publication of the Day

This study characterized the cytokine and chemokine responses to the 1st and 2nd dose of the BNT162b2 mRNA (Pfizer/BioNtech) vaccine in antigen-naïve and in previously COVID-19-infected individuals (NCT04743388).
Transient increases in IL-15 and IFN-γ levels early after boost correlated with Spike antibody levels, supporting their use as biomarkers of effective humoral immunity development in response to vaccination.
This study identified a systemic signature including IL-15, IFN-γ and IP-10/CXCL10 increase after the 1st vaccination, which was enriched by TNF-α and IL-6 after the 2nd vaccination.
In general, strong cytokine signature was found upon a single vaccination of convalescent persons and upon booster vaccination in naïve persons.

Publications

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
NEJM, July 21, 2021
Impact of original, B.1.1.7, and B.1.351/P.1 SARS-CoV-2 lineages on vaccine effectiveness of two doses of COVID-19 mRNA vaccines: Results from a nationwide case-control study in France
The Lancet, July 13, 2021
Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes
PNAS, July 2021
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination
Nature Medicine, July 14, 2021
Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Nature, July 12, 2021
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
Cell, July 6, 2021
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
Nature, July 8, 2021
Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine
NEJM, June 30, 2021
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
Nature, June 30, 2021
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Nature, June 28, 2021

News

At the F.D.A.’s urging, Pfizer-BioNTech and Moderna are expanding their studies of children 5 to 11.
NYT, July 26, 2021
Doctors, nurses and medical groups call for mandatory coronavirus vaccinations for health workers
Washington Post, July 26, 2021
Drop in UK COVID-19 cases indicates infection surge may be past peak
Reuters, July 26, 2021
Delta variant spreads globally as cases soar
BBC, July 25, 2021
New $40 million NIH study hopes to solve mysteries behind children’s long Covid-19
CNN, July 25, 2021
Pfizer vaccine effective against Delta variant of COVID-19 only after 2 doses: NEJM
Medical Dialogues, July 24, 2021
Covid vaccine: Eight-week gap seen as sweet spot for Pfizer jab antibodies
BBC, July 23, 2021
Moderna jab approved for teenagers in EU
BBC, July 23, 2021
The Downs And Ups Of Africa’s Current COVID Surge
NPR, July 23, 2021
Three states are seeing about 40% of the country’s new Covid-19 cases [US]
CNN, July 23, 2021
UK scientists back Covid boosters as study finds post-jab falls in antibodies
The Guardian, July 22, 2021