Publication of the Day
Neutralization of the SARS-CoV-2 Deltacron and BA.3 Variants
NEJM, May 18, 2022
- In serum samples obtained after 3 to 4 weeks of the second dose of the mRNA-1273, neutralizing-antibody titers were 3.3 times as low against the BA.3 variant and 44.7 times as low against the deltacron variant as compared with the response against the D614G variant.
- After booster, neutralizing-antibody titers were 2.9 times as low against the BA.3 variant and 13.3 times as low against the deltacron variant as against the D614G variant.
- In general, neutralization escape of the deltacron variant paralleled that of the BA.1 and BA.2 variants, whereas the BA.3 variant remained largely sensitive to neutralization.
- The patients who were hospitalized during the omicron wave had broader neutralization of all the tested omicron variants than did those hospitalized during the delta wave
Publications
- Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial
The Lancet eClinicalMedicine, May 12, 2022 - Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study
The Lancet Respiratory Medicine, May 11, 2022 - Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age
NEJM, May 11, 2022 - SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies
Cell Host & Microbe, May 5, 2022 - Omicron infection enhances Delta antibody immunity in vaccinated persons
Nature, May 6, 2022 - Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
The Lancet, May 2, 2022 - Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike
Cell, May 4, 2022 - Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection
JAMA, April 29, 2022 - An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
Science Immunology, April 26, 2022 - LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
Cell Reports, April 24, 2022 - Regional replacement of SARS-CoV-2 variant BA.1 with BA.2 as observed through wastewater surveillance
medRxiv, April 22, 2022
News
- Officials expected to decide on new COVID-19 vaccine design in early July
ABC News, May 20, 2022 - North Korea shuns outside help as COVID catastrophe looms
Al Jazeera, May 20, 2022 - CDC urges 2nd booster for older, high-risk Americans amid nation’s latest COVID-19 surge
ABC News, May 20, 2022 - How long does COVID-19 linger in your body? New report offers clues.
National Geographic, May 20, 2022 - New clue about why Covid is deadlier for men: Estrogen may play a protective role
NBC News, May 20, 2022 - The quest for longer-lasting Covid-19 vaccines
CNN, May 20, 2022 - Britain reduce COVID alert level as Omicron subsides
Reuters, May 20, 2022 - CDC signs off on boosters for 5-11-year-olds
CNN, May 19, 2022 - Omicron Infections, Without Vaccinations, Provide Little Immunity
GenEng News, May 19, 2022 - 1,000 cases of new Omicron subvariant BA.2.20 found in Ontario: PHO
CP24, May 19, 2022 - Nearly every state (US) expected to see increase in COVID-19 hospitalizations, forecast shows
ABC News, May 18, 2022 - A third of US should be considering masks, officials say
AP, May 18, 2022 - Study: 76% of long COVID patients were not initially hospitalized
Axios, May 18, 2022