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Top Headlines: North Korea shuns outside help as COVID catastrophe looms - Al Jazeera, May 20, 2022 CDC signs off on boosters for 5-11-year-olds - CNN, May 19, 2022 Omicron Infections, Without Vaccinations, Provide Little Immunity - GenEng News, May 19, 2022

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Important News and Publications

Publication of the Day

Neutralization of the SARS-CoV-2 Deltacron and BA.3 Variants 
NEJM, May 18, 2022 

  • In serum samples obtained after 3 to 4 weeks of the second dose of the mRNA-1273, neutralizing-antibody titers were 3.3 times as low against the BA.3 variant and 44.7 times as low against the deltacron variant as compared with the response against the D614G variant. 
  • After booster, neutralizing-antibody titers were 2.9 times as low against the BA.3 variant and 13.3 times as low against the deltacron variant as against the D614G variant. 
  • In general, neutralization escape of the deltacron variant paralleled that of the BA.1 and BA.2 variants, whereas the BA.3 variant remained largely sensitive to neutralization.  
  • The patients who were hospitalized during the omicron wave had broader neutralization of all the tested omicron variants than did those hospitalized during the delta wave  

Publications

  • Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial
    The Lancet eClinicalMedicine, May 12, 2022
  • Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study
    The Lancet Respiratory Medicine, May 11, 2022
  • Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age
    NEJM, May 11, 2022
  • SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies
    Cell Host & Microbe, May 5, 2022
  • Omicron infection enhances Delta antibody immunity in vaccinated persons 
    Nature, May 6, 2022
  • Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
    The Lancet, May 2, 2022
  • Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike
    Cell, May 4, 2022
  • Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection
    JAMA, April 29, 2022
  • An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
    Science Immunology, April 26, 2022 
  • LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
    Cell Reports, April 24, 2022
  • Regional replacement of SARS-CoV-2 variant BA.1 with BA.2 as observed through wastewater surveillance
    medRxiv, April 22, 2022

News

  • Officials expected to decide on new COVID-19 vaccine design in early July
    ABC News, May 20, 2022  
  • North Korea shuns outside help as COVID catastrophe looms
    Al Jazeera, May 20, 2022   
  • CDC urges 2nd booster for older, high-risk Americans amid nation’s latest COVID-19 surge
    ABC News, May 20, 2022   
  • How long does COVID-19 linger in your body? New report offers clues.
    National Geographic, May 20, 2022   
  • New clue about why Covid is deadlier for men: Estrogen may play a protective role
    NBC News, May 20, 2022   
  • The quest for longer-lasting Covid-19 vaccines
    CNN, May 20, 2022   
  • Britain reduce COVID alert level as Omicron subsides
    Reuters, May 20, 2022   
  • CDC signs off on boosters for 5-11-year-olds
    CNN, May 19, 2022   
  • Omicron Infections, Without Vaccinations, Provide Little Immunity 
    GenEng News, May 19, 2022 
  • 1,000 cases of new Omicron subvariant BA.2.20 found in Ontario: PHO
    CP24, May 19, 2022  
  • Nearly every state (US) expected to see increase in COVID-19 hospitalizations, forecast shows
    ABC News, May 18, 2022 
  • A third of US should be considering masks, officials say
    AP, May 18, 2022
  • Study: 76% of long COVID patients were not initially hospitalized
    Axios, May 18, 2022
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